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Pnpla2 knockout in muscle stem cells

ABSTRACT: Analysis of skeletal muscle satellite cells with specific knockout (KO) of Patatin-like phospholipase domain containing protein 2 (Pnpla2) gene in mouse (named Pnpla2PKO). Pnpla2 knockout disrupts lipid droplet catabolism in satellite cells and causes energy insufficiency and oxidative stress, accompanied by global lipid remodeling, which eventually impedes their expansion and fusion, leading to impairments in muscle regeneration.

ORGANISM(S): Mus musculus

PROVIDER: GSE150632 | GEO | 2022/01/01

REPOSITORIES: GEO

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