Transcriptomics

Dataset Information

0

Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment (single cells)


ABSTRACT: A hallmark of PD-1/L1 blockade is long-term, sustained remission of metastatic disease. How the immune system coordinates the destruction of macro- and micro-metastases following checkpoint blockade, however, remains unclear. Here, we show that tumor-expressed PD-L1 (tPD-L1) enhanced metastasis in a mechanism distinct from and independent of its role in primary tumor growth. This difference in metastatic growth was mediated by cytotoxic T lymphocytes (CTLs), however, tPD-L1 did not promote effector CTL exhaustion or suppress lytic activity in vivo. Instead, single cell RNA sequencing revealed that tPD-L1 engaged macrophage-expressed PD-1 to antagonize type I interferon production and signaling, creating an immunologically ‘cold’ microenvironment. Loss of tPD-L1 eliminated metastases by driving interferon-mediated sensitization of tumor cells to CTL lysis and CTL recruitment.

ORGANISM(S): Mus musculus

PROVIDER: GSE150742 | GEO | 2023/02/06

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2023-02-06 | GSE150739 | GEO
2024-03-30 | GSE242860 | GEO
2015-05-01 | E-GEOD-65041 | biostudies-arrayexpress
2023-06-16 | MSV000092193 | MassIVE
2023-09-26 | GSE214613 | GEO
2023-09-26 | GSE214485 | GEO
2023-11-17 | MODEL2310150001 | BioModels
2024-01-24 | PXD046384 | Pride
2020-04-21 | E-MTAB-9007 | biostudies-arrayexpress
2012-07-09 | E-GEOD-39205 | biostudies-arrayexpress