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Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE150793 | GEO | 2020/07/20

REPOSITORIES: GEO

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Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition [scRNA-seq]

Project description:Type 2 cytokine responses promote parasitic immunity and initiate tissue repair but, can also result in immunopathologies when not properly restricted. Basophilia is recognized as a common feature of type 2 inflammation, however, the roles basophils play in regulating these responses remain unknown. Here, we demonstrate that helminth-induced ILC2 responses are exaggerated in the absence of basophils, resulting in increased inflammation and diminished lung function. Additionally, we show that ILC2s from basophil-depleted mice express reduced levels of the receptor for the neuropeptide, neuromedin B (NMB). Critically, NMB stimulation inhibited ILC2 responses from control but not basophil-depleted mice, and basophils were sufficient to directly enhance NMB receptor (NMBR) expression on ILC2s. These studies suggest that basophils prime ILC2s to respond to neuron-derived signals necessary to maintain tissue integrity. Further, these data provide mechanistic insight into the functions of basophils and identify NMB as a potent inhibitor of type 2 inflammation.

2020-07-20 | GSE150792 | GEO

Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition [RNA-seq]

2020-07-20 | GSE152913 | GEO

Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition [bulk RNA-seq]

2020-07-20 | GSE150791 | GEO

Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition

Project description:Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition

| PRJNA633589 | ENA

Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition [scRNA-seq]

Project description:Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition [scRNA-seq]

| PRJNA633593 | ENA

Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition [RNA-seq]

Project description:Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition [RNA-seq]

| PRJNA640826 | ENA

Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition [bulk RNA-seq]

Project description:Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition [bulk RNA-seq]

| PRJNA633592 | ENA

The neuropeptide Neuromedin U stimulates innate lymphoid cells and promotes type 2 inflammation

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-08-18 | GSE101625 | GEO

Basophils promote innate lymphoid cell responses in inflamed skin.

Project description:Type 2 inflammation underlies allergic diseases such as atopic dermatitis, which is characterized by the accumulation of basophils and group 2 innate lymphoid cells (ILC2s) in inflamed skin lesions. Although murine studies have demonstrated that cutaneous basophil and ILC2 responses are dependent on thymic stromal lymphopoietin, whether these cell populations interact to regulate the development of cutaneous type 2 inflammation is poorly defined. In this study, we identify that basophils and ILC2s significantly accumulate in inflamed human and murine skin and form clusters not observed in control skin. We demonstrate that murine basophil responses precede ILC2 responses and that basophils are the dominant IL-4-enhanced GFP-expressing cell type in inflamed skin. Furthermore, basophils and IL-4 were necessary for the optimal accumulation of ILC2s and induction of atopic dermatitis-like disease. We show that ILC2s express IL-4Rα and proliferate in an IL-4-dependent manner. Additionally, basophil-derived IL-4 was required for cutaneous ILC2 responses in vivo and directly regulated ILC2 proliferation ex vivo. Collectively, these data reveal a previously unrecognized role for basophil-derived IL-4 in promoting ILC2 responses during cutaneous inflammation.

| S-EPMC4170007 | biostudies-literature

Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation.

Project description:Innate lymphocytes maintain tissue homeostasis at mucosal barriers, with group 2 innate lymphoid cells (ILC2s) producing type 2 cytokines and controlling helminth infection. While the molecular understanding of ILC2 responses has advanced, the complexity of microenvironmental factors impacting ILC2s is becoming increasingly apparent. Herein, we used single-cell analysis to explore the diversity of gene expression among lung lymphocytes during helminth infection. Following infection, we identified a subset of ILC2s that preferentially expressed Il5-encoding interleukin (IL)-5, together with Calca-encoding calcitonin gene-related peptide (CGRP) and its cognate receptor components. CGRP in concert with IL-33 and neuromedin U (NMU) supported IL-5 but constrained IL-13 expression and ILC2 proliferation. Without CGRP signaling, ILC2 responses and worm expulsion were enhanced. Collectively, these data point to CGRP as a context-dependent negative regulatory factor that shapes innate lymphocyte responses to alarmins and neuropeptides during type 2 innate immune responses.

| S-EPMC6801073 | biostudies-literature

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