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RNA sequencing of suprachiasmic nucleus (SCN) of mice with rev-erb / knockout in GABAergic neuron

ABSTRACT: We compared differentially expressed genes (DEGs) in isolated SCN of female wild-type and GABAergic neuron rev-erb / knockout (KO) mice at ZT12-14. 29 genes are significantly upregulated and 14 genes are statistically downregulated in SCN of KO mice. Aside from the circadian rhythm as an expected top-enriched functional entity, DEGs were enriched with cell surface proteins and associated modulators. Many of these genes are related to neurotransmission or neurological diseases.

ORGANISM(S): Mus musculus

PROVIDER: GSE150840 | GEO | 2021/03/24

REPOSITORIES: GEO

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| S-EPMC8085086 | biostudies-literature

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