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Single-cell copy number analysis in melanoma

ABSTRACT: We performed shallow single-cell copy number analysis across 1,475 cells from a melanoma COLO829 line, to resolve overall tumor complexity and clonality. We identified at least four major sub-clones by discriminant analysis of principal components (DAPC). Re-analysis of previous spectral karyotyping data recapitulated these sub-clone hallmark features and explains why previous experiments generated conflicting results. Overall, our results demonstrate how single cell sequencing can uncover significant hidden insights in a melanoma sample.

ORGANISM(S): Homo sapiens

PROVIDER: GSE151409 | GEO | 2020/05/29

REPOSITORIES: GEO

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