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Improved outcome of contusive spinal cord injury in Bmal1-/- mice is associated with protection of the blood spinal cord barrier

ABSTRACT: The purpose of the study is to understand the role of Bmal1 in spinal cord contusion.

ORGANISM(S): Mus musculus

PROVIDER: GSE151685 | GEO | 2023/06/01

REPOSITORIES: GEO

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Improved outcome of contusive spinal cord injury in Bmal1-/- mice is associated with protection of the blood spinal cord barrier

Project description:Improved outcome of contusive spinal cord injury in Bmal1-/- mice is associated with protection of the blood spinal cord barrier

| PRJNA636885 | ENA

Improved locomotor recovery after contusive spinal cord injury in Bmal1<sup>-/-</sup> mice is associated with protection of the blood spinal cord barrier.

Project description:The transcription factor BMAL1/ARNTL is a non-redundant component of the clock pathway that regulates circadian oscillations of gene expression. Loss of BMAL1 perturbs organismal homeostasis and usually exacerbates pathological responses to many types of insults by enhancing oxidative stress and inflammation. Surprisingly, we observed improved locomotor recovery and spinal cord white matter sparing in Bmal1-/- mice after T9 contusive spinal cord injury (SCI). While acute loss of neurons and oligodendrocytes was unaffected, Bmal1 deficiency reduced the chronic loss of oligodendrocytes at the injury epicenter 6 weeks post SCI. At 3 days post-injury (dpi), decreased expression of genes associated with cell proliferation, neuroinflammation and disruption of the blood spinal cord barrier (BSCB) was also observed. Moreover, intraspinal extravasation of fibrinogen and immunoglobulins was decreased acutely at dpi 1 and subacutely at dpi 7. Subacute decrease of hemoglobin deposition was also observed. Finally, subacutely reduced levels of the leukocyte marker CD45 and even greater reduction of the pro-inflammatory macrophage receptor CD36 suggest not only lower numbers of those cells but also their reduced inflammatory potential. These data indicate that Bmal1 deficiency improves SCI outcome, in part by reducing BSCB disruption and hemorrhage decreasing cytotoxic neuroinflammation and attenuating the chronic loss of oligodendrocytes.

| S-EPMC7450087 | biostudies-literature

Chronic contusion spinal cord injury in rats

Project description:Excerpt from a larger study which characterized the transcriptional effects of a spinal cord contusion injury in rats. This is the data from the almost chronic contusion state (35 days) at the injury site (Thoracic 8) - where we saw significant changes in several areas, including cholesterol metabolism genes. Other spinal cord areas (rostral, caudal) and time-points (3 hours, 24 hours, 7 days and 35 days) were analyzed as well and are discussed in our paper and at www.crpf.org/microarray. Keywords = Spinal Cord Injury Keywords = chronic Keywords = thoracic Keywords = cholesterol Keywords: repeat sample

2005-05-03 | GSE2599 | GEO

Transcription profiling of rat spinal cord contusion 35 days after injury

2007-10-08 | E-GEOD-2599 | biostudies-arrayexpress

trkB.T1 WT versus trkB.T1 KO expression data following spinal cord injury (SCI)

Project description:We profiled spinal cord tissue at the site of a moderate contusion injury at the level of the thoracic spinal cord We examined several timepoints following injury, including sham and days 1,3 and 7 following injury and compared differential expression of genes within a genotype and across genotypes (trkB.T1KO/trkB.T1WT) at each timepoint. Tissue was profiled at baseline (sham) condition and then 1, 3 and 7 days after thoracic moderate contusion injury

2013-08-05 | E-GEOD-47681 | biostudies-arrayexpress

miRNA expression after moderate Spinal Cord Injury in Rats

2011-07-01 | GSE19890 | GEO

miRNA expression after moderate Spinal Cord Injury in Rats

Project description:Identification of temporal variations in miRNA expression after spinal cord injury caused by thoracic (T8) moderate (200 Kdynes) contusion. Expression changes were analyzed 1, 3 and 7 days after injury and compared to expression of control (untreated) and sham (laminectony but no contusion) individuals. Included groups: control (untreated), 1 day after lesion, 3 days after lesion, 7 days after lesion, 1 days after SHAM cirugy, 3 days after SHAM cirugy, and 7 days after SHAM cirugy. Each of these 7 groups included 5 biological replicates.

2011-07-01 | E-GEOD-19890 | biostudies-arrayexpress

Spinal Cord Injury Murine Model

Project description:Traumatic spinal cord injury (SCI) initiates a complex series of pathophysiological secondary responses that lead to tissue loss and functional deficits.This study represents a comprehensive database of temporal changes in gene expression that underlie the secondary injury response that occurs in a well-defined mouse model of contusion injury. Keywords: Time-Series

2006-07-12 | GSE5296 | GEO

trkB.T1 WT versus trkB.T1 KO expression data following spinal cord injury (SCI)

2013-08-05 | GSE47681 | GEO

Expression data from rat spinal cord injury and mesenchymal stromal cells (MSC) or olfactory ensheathing cells (OEC) transplantation

Project description:We analyzed the changes in the spinal cord transcriptome after a spinal cord contusion injury and MSC or OEC transplantation. The cells were injected immediately or 7 days after the injury. The mRNA of the spinal cord injured segment was extracted and analyzed by microarray at 2 and 7 days after cell grafting.

2013-10-16 | GSE46988 | GEO

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