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Expression profiling of nasopharyngeal carcinoma cell lines

ABSTRACT: To identify the deregulated genes which may involved in the carcinogenesis of nasopharyngeal carcinoma (NPC). To identify potential tumor suppressor genes / oncogenes of NPC, we have employed whole genome microarray expression profiling as a discovery platform to analyze two NPC cell lines, TW01 and HONE1. For the purpose to filter out differential genes may not related to carcinogenesis of NPC, a gene expression database for premalignant nasopharyngeal epithelial cells was obtained from NP460hTert cells, and we used the commercial universal human RNA (stratagene) as common reference for all microarray experiments. A total of 1272 genes were commonly up-regulated (fold change > 2) and 1810 genes were commonly down-regulated (fold change < 0.5) in TW01 and HONE1 cell lines, whereas not deregulated in NP460hTert cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE15170 | GEO | 2010/03/09

SECONDARY ACCESSION(S): PRJNA123123

REPOSITORIES: GEO

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