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β cell specific Crif1 haploinsufficiency effect.

ABSTRACT: CRIF1 is a mitochondrial protein essential for the synthesis and formation of the OxPhos complex in the inner mitochondrial membrane. Beta cell specific Crif1 haploinsufficiency resulted in defect of first phase insulin secretion, and caused islet cell composition change as well as proliferation of beta cell for a compensation to maintain metabolic homeostasis. These results suggest that mitochondrial OxPhos function of beta cell has roles for beta cell compensation as well as insulin secretion.

ORGANISM(S): Mus musculus

PROVIDER: GSE151708 | GEO | 2022/07/21

REPOSITORIES: GEO

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β cell specific Crif1 haploinsufficiency effect.

Project description:β cell specific Crif1 haploinsufficiency effect.

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Differential gene expression analysis in liver, inguinal white adipose tissue (iWAT), skeletal muscle, and hypothalamus of mice with liver-specific Crif1 deficiency

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Mitochondrial regulator CRIF1 deficiency induces Foxp3low inflammatory non-suppressive regulatory-T cells in tumors [ATAC-seq]

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