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RNA-seq profiling of C/EBPβ-overexpressing myoblasts [proliferating myoblasts]

ABSTRACT: We previously identified C/EBPβ as an inhibitor of myogenic differentiation and a regulator of muscle satellite cell self-renewal. We found that C/EBPβ is regulated during the transition from proliferation to growth arrest in myoblasts and overexpression of C/EBPβ in myoblasts promotes cell growth arrest in vitro and improves engraftment of satellite cells into the stem cell niche in vivo. To identify the molecular mechanism by which C/EBPβ regulates myoblast proliferation and growth arrest, we performed RNA-seq on C/EBPβ-overexpressing myoblasts.

ORGANISM(S): Mus musculus

PROVIDER: GSE152051 | GEO | 2020/12/18

REPOSITORIES: GEO

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