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Affymetric SNP Array Data of 45 liver metastasis samples from colorectal cancer patients

ABSTRACT: To investigate genomic plasticity over time associated with response to standard chemotherapy, we collected longitudinal liver metastasis (LM) samples from 155 patients and characterized the copy number aberration (CNA) landscape and its effect on the transcriptome. CNA profiles of lesions exhibiting different treatment response were compared and focal genomic divergences reported. By investigating genomic-phenotype associations of the largest reported LM cohort to date, we identified novel molecular features associated with drug response supporting the relevance of collecting clinical metastatic samples.

ORGANISM(S): Homo sapiens

PROVIDER: GSE152178 | GEO | 2021/06/23

REPOSITORIES: GEO

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