Transcriptomics

Dataset Information

0

Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases


ABSTRACT: Lysophosphatidic acid (LPA) acts through high-affinity G protein-coupled receptors to mediate a plethora of physiological and pathological activities associated with tumorigenesis. LPA receptors and autotaxin (ATX/LysoPLD), the primary enzyme producing LPA, are aberrantly expressed in multiple cancer lineages. However, the role of ATX and LPA receptors in the initiation and progression of breast cancer has not been evaluated. We demonstrate that expression of ATX or each edg family LPA receptor in mammary epithelium of transgenic mice is sufficient to induce a high frequency of late-onset, estrogen receptor (ER)-positive, invasive, and metastatic mammary cancer. Thus, ATX and LPA receptors can contribute to the initiation and progression of breast cancer.

ORGANISM(S): Mus musculus

PROVIDER: GSE15263 | GEO | 2009/06/11

SECONDARY ACCESSION(S): PRJNA116489

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2016-11-30 | E-MTAB-4648 | biostudies-arrayexpress
2011-06-01 | GSE26442 | GEO
2024-10-06 | E-MTAB-14494 | biostudies-arrayexpress
2013-05-10 | E-MTAB-1169 | biostudies-arrayexpress
2011-06-01 | E-GEOD-26442 | biostudies-arrayexpress
2022-08-02 | GSE182062 | GEO
2024-11-12 | GSE262558 | GEO
2024-11-12 | GSE253361 | GEO
2024-11-12 | GSE253356 | GEO
| PRJNA116489 | ENA