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Single-cell Transcriptome Analysis Dissects the Replicating Process of Pancreatic Beta Cells in Partial Pancreatectomy Model.

ABSTRACT: We employed single-cell RNA sequencing of islets in young mice subjected to partial pancreatectomy (PPTx). Four clusters of pancreatic beta cells including a subpopulation of replicating beta cells. Pseudo-time course analysis clarified the gradual changes in gene expression from non-replicating beta cells to replicating ones. Upstream analysis visualized the transcriptional networks associated with beta cell replication by PPTx.

ORGANISM(S): Mus musculus

PROVIDER: GSE152730 | GEO | 2020/11/04

REPOSITORIES: GEO

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RNA sequencing discerns sub-populations of pancreatic β-cells and dynamics of gene expression in partial pancreatectomy model

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