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Genome-wide screening reveals the key genes that are responsible for trametinib-induced apoptosis

ABSTRACT: To explore the geness that are responsible for trametinib-induced apoptosis, we performed Genome-scale CRISPR-Cas9 knockout screening in GSU with 0.015% DMSO or 15 nM trametinib for 14 days. We found that TP53 is critical for executing trametinib-induced apoptosis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE152846 | GEO | 2023/06/19

REPOSITORIES: GEO

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