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Chromatin architecture landscape in hierarchical hematopoietic cells

ABSTRACT: The spatiotemporal chromatin reorganization during hematopoietic differentiation has not been well characterized, which partly limited by the large amounts of starting cells for the current high-throughput chromatin conformation capture approaches. Here, we introduce a low-input Hi-C method, tagHi-C, to capture the chromatin structures in hundreds of cells. We proved tagHi-C was a feasible and reproducible approach.

ORGANISM(S): Mus musculus

PROVIDER: GSE152918 | GEO | 2020/08/01

REPOSITORIES: GEO

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