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CELF1 upregulates MMP gene expression to regulate cataract development

ABSTRACT: As a multifunctional RBP, CELF1 is known to preferentially binds to GU-rich elements (GREs) predominantly located in 3’ untranslated regions(UTRs) of target mRNA to regulate various post-transcriptional process. However, the targeted genes that regulated by CELF1 during cataractogenesis remains unknown. In present study,the function of CELF1 in SRA01/04 cells was investigated with CELF1 overexpression, the expression of MMPs was regulated by CELF1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE153022 | GEO | 2022/03/23

REPOSITORIES: GEO

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CELF1 upregulates MMP gene expression to regulate cataract development

Project description:CELF1 upregulates MMP gene expression to regulate cataract development

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