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The role of Itgb1 in islet development

ABSTRACT: Pancreatic development requires appropriate environmental cues, in which ECM-Integrin signaling plays a central role in the process. Specifically, we investigated how ECM-Integrin signaling in Ngn3+ cell (endocrine progenitors) regulates islet architecture and functions. Here we showed disruption of ECM-Integrin signaling affects beta cell functional maturation and potential non-autonomous regulation around islets.

ORGANISM(S): Mus musculus

PROVIDER: GSE153187 | GEO | 2023/06/22

REPOSITORIES: GEO

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The role of Itgb1 in islet development

Project description:The role of Itgb1 in islet development

| PRJNA641689 | ENA

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