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Notch signaling between cerebellar granule cell progenitors

ABSTRACT: During cerebellar development, maternal granule cell progenitors (GCPs) divide to produce not only postmitotic granule cells (GCs) but also sister GCPs. However, molecular machinery to proportionally produce distinct sister cell types from seemingly uniform GCPs is still elusive. Here we report Notch signaling makes a difference among GCPs, leading to their proportional differentiation.

ORGANISM(S): Mus musculus

PROVIDER: GSE153313 | GEO | 2020/06/27

REPOSITORIES: GEO

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