Transcriptomics

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RNA-seq analysis of rat neurons treated with shRNA-mediated Trank1 knockdown


ABSTRACT: Genetic analyses for bipolar disorder (BPD) have achieved prominent success in Europeans in recent years, whereas its genetic basis in other populations remains relatively less understood. We herein report that the lead risk locus for BPD in European genome-wide association studies (GWAS), the single nucleotide polymorphism (SNP) rs9834970 near TRANK1 at 3p22 region, is also genome-wide significantly associated with BPD in 5,748 cases and 65,361 controls of East Asian origin. In this study, we performed RAN-seq analysis of cultured rat neurons treated with shRNA knockdown of Trank1.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE153638 | GEO | 2020/07/02

REPOSITORIES: GEO

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