Antagonistic roles for Ataxin-2 structured and disordered domains in RNP condensatation
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ABSTRACT: Ataxin-2 is a conserved translational control protein as well as an important target for ALS therapeutics under development. Despite its clinical and biological significance, Ataxin-2’s activities, mechanisms and functions are not well understood. Using Drosophila Ataxin-2 (Atx2) we investigate how Ataxin-2 IDRs work with structured (Lsm, Lsm-AD and PAM2) domains to enable positive and negative regulation of target mRNAs. Using TRIBE (Targets of RNA-Binding Proteins Identified by Editing) technology, we identified and analysed Atx-2 target mRNAs in the Drosophila brain.
ORGANISM(S): Drosophila melanogaster
PROVIDER: GSE153985 | GEO | 2021/03/03
REPOSITORIES: GEO
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