Transcriptomics

Dataset Information

0

Antagonistic roles for Ataxin-2 structured and disordered domains in RNP condensatation


ABSTRACT: Ataxin-2 is a conserved translational control protein as well as an important target for ALS therapeutics under development. Despite its clinical and biological significance, Ataxin-2’s activities, mechanisms and functions are not well understood. Using Drosophila Ataxin-2 (Atx2) we investigate how Ataxin-2 IDRs work with structured (Lsm, Lsm-AD and PAM2) domains to enable positive and negative regulation of target mRNAs. Using TRIBE (Targets of RNA-Binding Proteins Identified by Editing) technology, we identified and analysed Atx-2 target mRNAs in the Drosophila brain.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE153985 | GEO | 2021/03/03

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-04-22 | GSE196739 | GEO
2021-02-05 | GSE165677 | GEO
2014-06-20 | E-GEOD-53189 | biostudies-arrayexpress
2023-11-17 | GSE234468 | GEO
2014-06-20 | GSE53189 | GEO
| PRJNA644650 | ENA
2021-12-29 | GSE185473 | GEO
| S-EPMC7946432 | biostudies-literature
2020-02-18 | E-MTAB-7713 | biostudies-arrayexpress
2022-10-18 | GSE200530 | GEO