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ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1

ABSTRACT: ENO1 (α-Enolase 1) is a key glycolytic enzyme that catalyzes the dehydratation of 2-phosphoglycerate to phosphoenolpyruvate. It also belongs to a member of the RNA degradosome of Escherichia coli and facilitates RNA degradation, but it’s currently unknown whether ENO1 possesses similar function in eukaryotes. To test this possibility,we performed RNA-seq assays expressing NTC or ENO1 shRNA, respectively.

ORGANISM(S): Homo sapiens

PROVIDER: GSE153989 | GEO | 2021/09/10

REPOSITORIES: GEO

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ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism

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