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Heat shock protein gp96 induces Foxp3 expression in Regulatory T Cells via interaction with TLRs for treatment of Auto-immune Diseases [Foxp3Cre Myd88fl/fl]

ABSTRACT: Upregulate and stabilize Foxp3 expression in Treg are essential for manipulating Treg cell function and immune homeostasis. Here, we examined the potential role and mechanism of gp96 protein in regulating FoxP3 transcription and Treg activation in vivo.

ORGANISM(S): Mus musculus

PROVIDER: GSE154172 | GEO | 2020/07/11

REPOSITORIES: GEO

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Heat shock protein gp96 induces Foxp3 expression in Regulatory T Cells via interaction with TLRs for treatment of Auto-immune Diseases [FFoxp3-GFP-hCre]

Project description:Upregulate and stabilize Foxp3 expression in Treg are essential for manipulating Treg cell function and immune homeostasis. Here, we examined the potential role and mechanism of gp96 protein in regulating FoxP3 transcription and Treg activation in vivo.

2020-07-11 | GSE154173 | GEO

Heat shock protein gp96 induces Foxp3 expression in Regulatory T Cells via interaction with TLRs for treatment of Auto-immune Diseases [Foxp3Cre Myd88fl/fl]

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Heat shock protein gp96 induces Foxp3 expression in Regulatory T Cells via interaction with TLRs for treatment of Auto-immune Diseases

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Human Treg LC-MSMS - Foxp3 drives oxidative phosphorylation and protection from lipotoxicity

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Tregs from Bcl11b-deficient versus wild type Tregs (CD4Cre and Foxp3Cre systems)

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