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Comparison of the RB loss-induced transcrptiome in hormone-therapy sensitive and castration-resistant prostate cancer [RNA-seq]

ABSTRACT: These studies examine the biological networks altered after RB loss across prostate cancer progression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE154190 | GEO | 2021/04/26

REPOSITORIES: GEO

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Comparison of the RB loss-induced E2F1 cistrome in hormone-therapy sensitive and castration-resistant prostate cancer [ChIP-seq]

Project description:These studies examine the consequence of RB loss on E2F1 function across prostate cancer progression.

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Comparison of the RB loss-induced transcrptiome in hormone-therapy sensitive and castration-resistant prostate cancer

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Comparison of the RB loss-induced transcrptiome in hormone-therapy sensitive and castration-resistant prostate cancer

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Comparison of the RB loss-induced transcrptiome in hormone-therapy sensitive and castration-resistant prostate cancer [RNA-seq]

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Comparison of the RB loss-induced E2F1 cistrome in hormone-therapy sensitive and castration-resistant prostate cancer [ChIP-seq]

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Identifying the patients with rapid progression from hormone-sensitive to castration-resistant prostate cancer

Project description:We collected 78 biopsies and analyzed the proteomic expression by pressure cycling technology and Pulsed data-independent acquisition (PCT-PulseDIA) pipeline. Next, we explore the differentially expressed proteins (DEPs) in the discovery set (n=16) which contains short (S, n=8)- and long (L, n=8)- term progression. The progression-related proteins were further identified in another dataset, modeling set (n=62), utilizing the ANOVA estimation and random forest model. Multivariable Cox regression analysis was then conducted to determine clinical and protein variables significantly associated with the progression of HSPC in the whole sample set (n=78).

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Monitoring Patients with Metastatic Hormone-Sensitive and Metastatic Castration-Resistant Prostate Cancer: A Multidisciplinary Consensus Document.

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