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Transcriptomic analysis of the effects of CDK8 and CDK19 knockout and re-expression and selective CDK8/19 kinase inhibitor Senexin B treatment on gene expression in HEK293 cells

ABSTRACT: RNA-Seq analysis was carried out to investigate the effects of selective CDK8/19 inhibitor Senexin B (different treatment period) and knockout/re-expression of CDK8 and CDK19 proteins) on gene transcription in HEK293 cells

ORGANISM(S): Homo sapiens

PROVIDER: GSE154357 | GEO | 2022/07/01

REPOSITORIES: GEO

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Effects of CDK8/19 Mediator Kinase inhibition by Senexin B on gene expression in HEK293 cells

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Project description:We have investigated the effects of CDK8/19 inhibitor Senexin A on NFκB-mediated transcription, induced by a canonical NFκB activator, TNFα.

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Project description:Transcriptomic analysis of the effects of CDK8 and CDK19 knockout and re-expression and selective CDK8/19 kinase inhibitor Senexin B treatment on gene expression in HEK293 cells

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