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RNA sequence of gestational diabetes mellitus (GDM) and healthy control placentas

ABSTRACT: GDM is a multi-system disorder that is primarily characterised by new-onset hypertension accompanied by proteinuria during gestation. This disease is one of the leading causes of maternal and perinatal morbidity and mortality. In this work, placental samples were collected from GDM and control patients. RNA-seq was performed to identify differences in gene expression. Significantly differentially expressed genes between the GDM and control samples included 64 up-regulated and 296 down-regulated genes. This study may provide further insight in the mechanisms of GDM and function as preventive, predictive and therapeutic measures.

ORGANISM(S): Homo sapiens

PROVIDER: GSE154414 | GEO | 2021/12/31

REPOSITORIES: GEO

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Expression profiles of placenta and umbilical cord blood with or without gestational diabetes mellitus (GDM)

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RNA sequence of gestational diabetes mellitus (GDM) and healthy control placentas

Project description:RNA sequence of gestational diabetes mellitus (GDM) and healthy control placentas

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Project description:We compared the plasma miRNA expression profiles between healthy and GDM women by microarray analysis.Our study offers new insights into circulating biomarkers of GDM and thus provides a valuable resource for future investigations.

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