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Gene expression profiling in mouse liver infected with Clonorchis sinensis metacercariae.

ABSTRACT: Analysis of host response to the infected Clonorchis sinensis metacercariae and adult worm. The infected tissues evidenced altered expression of genes involved in systems such as immune response and cell cycle regulation, as compared with normal tissues.

ORGANISM(S): Mus musculus

PROVIDER: GSE15447 | GEO | 2009/04/01

SECONDARY ACCESSION(S): PRJNA115813

REPOSITORIES: GEO

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Gene expression profiling in mouse liver infected with Clonorchis sinensis metacercariae.

Project description:Analysis of host response to the infected Clonorchis sinensis metacercariae and adult worm. The infected tissues evidenced altered expression of genes involved in systems such as immune response and cell cycle regulation, as compared with normal tissues. Total RNA obtained from isolated liver tissues subjected to 1, 2, 4, and 6 weeks post-infection compared to uninfected liver tissues.

2010-05-20 | E-GEOD-15447 | biostudies-arrayexpress

Characterization of small RNAs in the different developmental stages of carcinogenic parasite-Clonorchis sinensis

Project description:Clonorchiasis is a foodborne zoonotic disease caused by Clonorchis sinensis which belongs to trematodes with a complex lifecycle, there are increasing evidences that small RNAs including microRNAs and PIWI-interacting RNAs can participate in regulation of embryonic development. However, there is little information about the small RNAs in the different developmental stages of C. sinensis. In the present study, we investigated profiles of miRNAs and piRNAs in the different developmental stages including eggs, metacercaria and adults of C. sinensis using high-throughout sequencing technology. We found that 152 miRNAs for adults, 147 miRNAs for metacercariae and 161 miRNAs for eggs were identified, of these miRNAs, 52 miRNAs were universally expressed in these three developmental stage. For piRNAs, we also found that there were a total of 4573 piRNAs in adult worms, 3189 piRNAs in eggs and 3853 piRNAs in metacercariae, respectively, and 1127, 426, 756 piRNAs were absolutely expressed only in adults, eggs and metacercariae, respectively. These stage-specific small RNAs might be involved in various biological process and environmental adaption for parasitism as showed by GO and KEGG pathway analysis. The data of present study may provide a basis for future targeting at these stage-specific small RNAs for prevention and control clonorchisias.

2021-12-01 | GSE137695 | GEO

Dysregulation of hepatic microRNA expression profiles with Clonorchis sinensis infection

Project description:Clonorchiasis remains an important zoonotic parasitic disease worldwide. The molecular mechanisms of host-parasite interaction are not fully understood. Non-coding microRNAs (miRNAs) are considered to be key regulators in parasitic diseases. The regulation of miRNAs and host micro-environment may be involved in clonorchiasis, and require further investigation. MiRNA microarray technology and bioinformatic analysis were used to investigate the regulatory mechanisms of host miRNA and to compare miRNA expression profiles in the liver tissues of Clonorchis sinensis-infected rats and controls.A total of eight miRNAs were downregulated and two were upregulated, which showed differentially altered expression profiles in the liver tissue of C. sinensis-infected rats. Further analysis of the differentially expressed miRNAs revealed that many important signal pathways were triggered after infection with C. sinensis, which were related to clonorchiasis pathogenesis, such as cell apoptosis and inflammation, as well as genes involved in signal transduction mechanisms, such as pathways in cancer and the Wnt and Mitogen-activated protein kinases (MAPK) signaling pathways.This dysregulation in miRNA expression may contribute to the etiology and pathophysiology of clonorchiasis. These results also provide new insights into the regulatory mechanisms of miRNAs in clonorchiasis, which may present potential targets for future C. sinensis control strategies.

2016-10-14 | GSE88708 | GEO

Human cholangiocarcinoma cells treated with Clonorchis sinensis excretory-secretory products.

Project description:Clonorchiasis is associated with bile duct malignancy and the subsequent development of cholangiocarcinoma. Although this is likely caused by adult Clonorchis sinensis and its excretory-secretory products (ESP), the precise molecular mechanisms remain obscure. To evaluate the effect of C. sinensis infection on differential gene expression in host hepatocytes, we used cDNA microarrays in human cholangiocarcinoma cells through the mimicking of C. sinensis infestation, and analyzed differential mRNA expression patterns of host cells. Keywords: Time course

2008-07-24 | GSE12213 | GEO

Clonorchis sinensis transcriptome

Project description:Clonorchis sinensis transcriptome

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Project description:Clonorchis sinensis Raw sequence reads

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Clonorchis sinensis

Project description:Clonorchis sinensis Raw sequence reads

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Clonorchis sinensis

Project description:Clonorchis sinensis whole-genome sequencing

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Clonorchis sinensis transcriptome

Project description:We conducted transcriptome sequencing of Clonorchis sinesis sub-organs (sucker, muscle, ovary and testis) with Illumina sequencing.

2013-01-30 | E-MTAB-827 | biostudies-arrayexpress

Gene expression in the livers of rats with no infection and at 2 and 4 weeks after Clonorchis sinensis infection

Project description:We examined gene expression profiles (27028 genes) in the livers of Sprague-Dawley rats with no infection and at 2 and 4 weeks after Clonorchis sinensis infection using Whole Rat Genome Microarray 4x44K v3 (GPL14745, Agilent-028282)

2019-08-29 | GSE136575 | GEO

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