Notch activity determines a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features [Venus]

ABSTRACT: Hepatocellular carcinoma (HCC) is the predominant primary liver cancer and an increasing cause of cancer-related deaths worldwide, due in part through increased obesity-associated nonalcoholic steatohepatitis (NASH) and associated fibrosis. The Notch signaling pathway is inappropriately “reactivated” in hepatocytes in obesity and plays an active role in the pathogenesis of NASH-associated fibrosis. We aimed to understand the involvement of Notch in the pathogenesis of mouse and human HCC.

ORGANISM(S): Mus musculus

PROVIDER: GSE154550 | GEO | 2020/09/28

REPOSITORIES: GEO