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Regnase-1 KO CAR T cell reprogramed to memory-like cells

ABSTRACT: transcriptional profiling was performed on WT and KO CAR T cells isolated 21 days after co-transfer into tumor bearing mice. Regnase-1 KO CAR T cell reprogramed to memory-like cells long-term after tumor priming in vivo compared to WT CAR T cells

ORGANISM(S): Mus musculus

PROVIDER: GSE154942 | GEO | 2021/07/08

REPOSITORIES: GEO

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Improved persistence and expanded TPEX formation in Regnase-1 KO CAR T cells is TCF-1-dependent

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