Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression by BTF3 knocked down in MDA-MB-231 cells

ABSTRACT: The aim of this research was to confirm the regulatory effect of BTF3 on gene expression in the development of TNBC.

ORGANISM(S): Homo sapiens

PROVIDER: GSE155168 | GEO | 2022/07/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Gene expression by BTF3 knocked down in Vcap cells

Project description:The aim of this research was to confirm the regulatory effect of BTF3 on gene expression in the development of prostate cancer.

2019-06-21 | GSE122749 | GEO

RNAi profiling of human MDA-MB-231 cells knocked down for RhoGDIbeta

Project description:RhoGDIbeta (ARHGDIB) is often expressed in tumor cells. It negatively regulates Rho-GTPases, but may have other functions as well. To analyze its effect on gene expression, RhoGDIbeta was suppressed by RNA interference in MDA-MB-231 breast cancer cells and changes in gene expression monitored by cDNA microarrays. Experiment Overall Design: MDA-MB-231 cells were either transfected with a RhoGDIbeta-specific siRNA or a control siRNA (siLuc), grown for three days, harvested and lysed for total RNA isolation. RNA was subjected to cDNA microarray analysis by using Affymetrix chip HG-U133A. A total of three independent transfection experiments were performed. The samples obtained from experiments 1, 2 and 3 were designated as siLuc_rep1, siLuc_rep2, siLuc_rep3 (siLuc transfected) and siARH_rep1, siARH_rep2, siARH_rep3 (siRhoGDIbeta transfected), respectively.

| S-ECPF-GEOD-8087 | biostudies-other

Gene expression by basic transcription factor 3 (BTF3）knocked out in HCT116

Project description:The aim of this research was to confirm the regulatory effect of basic transcription factor 3 (BTF3) on gene expression in the development of rectal cancer.

2017-03-18 | GSE96755 | GEO

Gene expression by BTF3 knocked down in MDA-MB-231 cells

Project description:Gene expression by BTF3 knocked down in MDA-MB-231 cells

| PRJNA648912 | ENA

siRNA profiling of human cancer cell line MDA-MB-231 knocked down for CD146 mRNA

Project description:Metastasis is a complex process involving loss of adhesion, migration, invasion and proliferation of cancer cells. Cell adhesion molecules play a pivotal role in this phenomenon by regulating cell-cell and cell-matrix interactions. CD146 (MCAM) is associated with advanced tumor stage in melanoma, prostate and ovarian cancers. For this study, the MDA-MB-231 cell line was used as a prototypic mesenchymal and invasive cell line, spontaneously expressing high levels of CD146. Using whole-genome DNA microarrays, we investigated genes for which expression was modified by CD146 down-regulation, obtained by siRNA or shRNA technology Experiment Overall Design: Expression profiles of two cell lines transfected by two differents ShRNA directed against CD146 were compared with expression profiles of 3 control cell lines (i.e. native cell line, empty plasmid and shRNA directed against GFP)

| S-ECPF-GEOD-11951 | biostudies-other

RNAi profiling of human MDA-MB-231 cells knocked down for RhoGDIbeta

2008-06-15 | E-GEOD-8087 | biostudies-arrayexpress

Expression data from ELK3 knocked down MDA-MB-231 cell line.

Project description:Triple-negative breast cancer is a highly aggressive tumor subtype that lacks effective therapeutic targets. Here, we show that ELK3 is overexpressed in a subset of breast cancers, in particular basal-like and normal-like/claudin-low cell lines. Suppression of ELK3 in MDA-MB-231 cells led to transdifferentiation from an invasive mesenchymal phenotype to a non-invasive epithelial phenotype both in vitro and in vivo. Suppression of ELK3 results in the extensive changes in genome expression profiles. Among these, GATA3, a master suppressor of metastasis, was epigenetically activated and we found that suppression of GATA3 led to the restoration of migration and invasion. These results suggest that the ELK3-GATA3 axis is a major pathway that promotes metastasis of MDA-MB-231 cells.

2016-06-15 | GSE83325 | GEO

Gene expression by TRPS1 knocked down in T47D

Project description:The aim of this research was to confirm the regulatory effect of TRPS1 on gene expression in the development of breast cancer.

2018-11-19 | GSE104062 | GEO

Expression data from ELK3 knocked down MDA-MB-231 cell line.

2016-06-15 | E-GEOD-83325 | biostudies-arrayexpress

Gene expression by LASP1 knocked down in PC3 cells

Project description:The aim of this research was to confirm the regulatory effect of LASP1 on gene expression in the development of prostate cancer.

2022-07-01 | GSE155731 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data