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Genetic and immunohistochemical analysis in a case of pleuropulmonary blastoma with renal tumor and small bowel polyps

ABSTRACT: The genetic cause for PPB in association with renal tumor and small bowel polyps remains to be identified. Activation of components of the mTOR signalling pathway in the disease lesions suggests that this signal transduction route may be involved in disease pathogenesis and that rapamycin, an inhibitor of mTOR, might be effective in the treatment of PPB and associated lesions.

ORGANISM(S): Homo sapiens

PROVIDER: GSE15521 | GEO | 2010/04/02

SECONDARY ACCESSION(S): PRJNA115693

REPOSITORIES: GEO

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Genetic and immunohistochemical analysis in a case of pleuropulmonary blastoma with renal tumor and small bowel polyps

Project description:The genetic cause for PPB in association with renal tumor and small bowel polyps remains to be identified. Activation of components of the mTOR signalling pathway in the disease lesions suggests that this signal transduction route may be involved in disease pathogenesis and that rapamycin, an inhibitor of mTOR, might be effective in the treatment of PPB and associated lesions. A combination of molecular cytogenetics and gene-specific mutation screens were performed to search for an underlying genetic cause for PPB in association with small bowel polyps. Immunohistochemical analysis to measure mTOR activation was performed on tissue from renal and lung tumor and small bowel polyps from the index case

2010-04-02 | E-GEOD-15521 | biostudies-arrayexpress

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Ablation of Lgr5-positive cells in intestinal polyps from ApcMin;Lgr5DTR mice

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Expression data from hyperplastic polyps and normal colonic mucosa from patients with familial and sporadic HPPS

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Gene expression analysis of microvesicular hyperplastic polyps and sessile serrated polyps/adenomas

Project description:In this study we compared gene expression of precancerous SSA/Ps and benign MVHPs with particular focus on genes involved in colorectal cancer. We also identify genes whose expression can be used to differentiate SSA/Ps and MVHPs. These results provide insight into the development of SSA/Ps and illustrates differences between these related colonic polyps. Total RNA from 6 samples of normal colon, 6 microvesicular hyperplastic polyps, and 6 sessile serrated adenomas/polyps were compared

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Expression data from hyperplastic polyps and normal colonic mucosa from patients with familial and sporadic HPPS

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Small RNA sequencing of sessile serrated polyps identifies miRNA profile associated with colon cancer

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Persistent Effect of mTOR Inhibition on Preneoplastic Foci Progression and Gene Expression in a Rat Model of Hepatocellular Carcinoma

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