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Unveiling the role of RAB13 localisation in angiogenesis

ABSTRACT: Deciphering the complex biology of cell migration is key to understand human-related disorders. During angiogenesis, endothelial cells engage in coordinated migration events to form new blood vessels from parental counterparts. However, while subcellular localisation of mRNAs and localised translation are fundamental steps between gene transcription and protein activity, whether local regulation of gene expression controls the complex morphogenetic process of angiogenesis has never been addressed. Here, we focused on RAB13 mRNA, a transcript enriched at the leading front of many migratory cell types. We set out to delete regions in the 3'UTR of RAB13 mRNA responsible for its subcellular distribution in vitro and in vivo and to study its localised role during angiogenesis.

ORGANISM(S): Danio rerio Homo sapiens

PROVIDER: GSE155449 | GEO | 2020/09/07

REPOSITORIES: GEO

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Unveiling the role of RAB13 localisation in angiogenesis

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