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Gene expression of aorta of ApoE KO mice after Gpnmb vaccine treatment

ABSTRACT: Accumulation of senescent cells in various tissues has been reported to have a pathological role in age-associated diseases. Inhibition of cellular aging signals prevents the onset of age-associated pathology, but there is a risk of promoting carcinogenesis. Elimination of senescent cells (senolysis) was recently reported to reversibly improve pathological changes related to aging in aged mice without increasing the development of cancer. Here we report that glycoprotein nonmetastatic melanoma protein B (Gpnmb) could be a molecular target for senolytic therapy. Elimination of Gpnmb-positive cells by vaccination improved atherosclerosis.

ORGANISM(S): Mus musculus

PROVIDER: GSE155596 | GEO | 2021/10/22

REPOSITORIES: GEO

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