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Transcriptomic profiling of canine osteosarcoma and non-malignant bone

ABSTRACT: Dogs develop osteosarcoma (OSA) and the disease process closely resembles that of human OSA. OSA has a poor prognosis in both species and disease free intervals and cure rates have not improved in recent years. Gene expression in canine OSAs was compared with non-tumor tissue utilising next generation RNA sequencing. The data provides novel insights into the molecular mechanisms of OSA in high risk breeds. This knowledge may inform development of prevention and treatment for OSA in dogs and supports the dog as a model of OSA in people.

ORGANISM(S): Canis lupus familiaris

PROVIDER: GSE155646 | GEO | 2020/10/22

REPOSITORIES: GEO

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