CCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP/TAZ signalling
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ABSTRACT: We report that loss of CCM3/PDCD10 in fibroblasts induces FAK/Src-paxillin signalling driving actomyosin-dependent mechanotransduction leading to YAP/TAZ signalling. In vivo, loss of CCM3 in fibroblasts drives excessive tissue remodelling leading to the dissemination of breast cancer cells to distant organs.
ORGANISM(S): Homo sapiens
PROVIDER: GSE155688 | GEO | 2021/05/06
REPOSITORIES: GEO
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