Transcriptomics

Dataset Information

0

Genome-wide expression profiling of acute promyelocytic leukemia NB4 cells treated with all-trans-retinoic acid


ABSTRACT: Acute promyelocytic leukemia (APL) is a hematological disease characterized by a balanced reciprocal translocation that leads to the synthesis of the oncogenic fusion protein PML-RARα. APL is mainly managed by a differentiation therapy based on the administration of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). However, therapy resistance, differentiation syndrome, and relapses require the development of new low-toxicity therapies based on the induction of blasts differentiation. Here, we performed a high-throughput gene expression profile of the maturation inducible APL cell line NB4 untreated or exposed to ATRA.

ORGANISM(S): Homo sapiens

PROVIDER: GSE155779 | GEO | 2020/11/05

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-01-01 | GSE223329 | GEO
2013-08-02 | E-GEOD-42031 | biostudies-arrayexpress
2013-08-02 | GSE42031 | GEO
2017-05-12 | GSE95637 | GEO
2019-12-18 | PXD008761 | Pride
2016-09-01 | E-GEOD-73157 | biostudies-arrayexpress
2024-06-23 | PXD050317 | Pride
2016-09-01 | GSE73157 | GEO
2014-04-30 | GSE49516 | GEO
2010-12-01 | E-GEOD-23702 | biostudies-arrayexpress