Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ScRNASeq data of CD45+CD3-CD19- and keratinocytes in normal and HS skin

ABSTRACT: Hidradenitis suppurativa (HS) is a highly prevalent, morbid inflammatory skin disease with limited treatment options. The major cell types and inflammatory pathways in skin of HS patients are poorly understood. We profiled via scRNASeq myeloid cells and keratinocytes sort-purified from two healthy skin samples and two samples with HS pathology to determine major cell types and transcriptional pathways altered in HS.

ORGANISM(S): Homo sapiens

PROVIDER: GSE155850 | GEO | 2020/08/27

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

scRNASeq Data of CD3 Negative Immune Cells in HS lesional skin, healthy skin, and matched blood

Project description:Hidradenitis suppurativa (HS) is an inflammatory skin disease with limited therapeutic options. We and others have previously identified an abnormal B cell infiltrate within HS lesional skin. We performed scRNASequencing on CD3 negative cells from inflammatory HS skin lesions, healthy control skin and matched blood to better understand infiltrating B cells amongst other immune cells within lesional skin.

2023-12-10 | GSE249793 | GEO

scRNASeq Data of CD45- cells in HS lesional skin and healthy skin

Project description:Hidradenitis suppurativa (HS) is an inflammatory skin disease with limited therapeutic options. Identifying transcriptional alterations within non-immune populations of HS lesions versus healthy controls could identify novel targets for therapy. We profiled subsets sorted as live, CD45 negative cells from biopsies of inflammatory lesions of three patients with HS and six specimens from healthy controls to determine what cell types and pathways were altered in HS inflammatory lesions.

2023-12-07 | GSE249621 | GEO

scRNASeq Data of CD4 Tregs and Teffectors in HS lesional skin and healthy skin

Project description:Hidradenitis suppurativa (HS) is an inflammatory skin disease with limited therapeutic options. CD4 T Cells have been described as more inflammatory than T cells in healthy skin. To better understand alterations within the T cell compartment, we profiled CD4 Teffector cells and regulatory T cells (Treg) from inflammatory HS skin lesions and healthy control skin via scRNASequencing.

2023-12-07 | GSE249622 | GEO

Spatial transcriptomics data of HS lesional skin and healthy skin

Project description:Hidradenitis suppurativa (HS) skin lesions are infiltrated by numerous inflammatory cell types, which may be subject to and can act upon surrounding tissue stroma and epithelium. Understanding how these networks are locally organized can help identify key nodes sustaining inflammatory and fibrotic processes.

2023-12-10 | GSE249729 | GEO

Transcriptome of skin biopsies from Hidradenitis Suppurativa (HS) patients with anti-TNFalpha therapy.

Project description:Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder with significant morbidity. The pathogenesis remains incompletely understood although immune dysregulation plays an important role. It is challenging to treat and approximately 50% of patients respond clinically to adalimumab, the only licensed treatment.

2022-09-25 | GSE213761 | GEO

Replication Stress in Hair-Follicle-Stem-Cell Leads to IFI16-STING dependent inflammation in Hidradenitis Suppurativa

Project description:Hidradenitis suppurativa (HS) is a chronic, relapsing, inflammatory skin disease. We characterized hair follicle stem cells isolated from HS and healthy (HD) patients and more precisely the Outer Root Sheath Cells (ORS). We show that transcriptomic analyses of hair follicles from HS (n=6) and HD (n=5) revealed an interferon signature and an alteration of cell cycle pathways

2020-07-08 | GSE147586 | GEO

HS microbiome

Project description:The skin microbiome in Hidradenitis Suppurativa

| PRJEB15266 | ENA

Single cell transcriptional profile for hidradenitis suppurativa

Project description:Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with a relapsing, remitting course. The disorder is characterized by painful abscesses and nodules in areas with high sweat gland and hair follicle density. The pathogenesis of HS is still incompletely understood. To provide insight into the cellular landscape of HS lesions, we utilized single-cell RNA sequencing (scRNA-seq) technology.

2021-09-13 | GSE175990 | GEO

RNA sequencing of skin punch biopsies of lesional and non-lesional skin from hidradenitis suppurativa patients

Project description:This study investigated the underlying inflammatory pathways and cell types in hidradenitis suppurativa using transcriptomic approaches with RNA sequencing of lesional and non-lesional skin biopsies from hidradenitis suppurativa patients.

2023-12-06 | GSE249027 | GEO

Transcriptome-wide analysis of hidradenitis suppurativa

Project description:The aim of this study was to obtain a better understanding of the molecular background of hidradenitis suppurativa (HS). Global transcriptome analysis of lesional and perilesional skin identifies numerous differentially expressed genes that display unique expression pattern in HS. Genes, whose expression is dysregulated in the skin of patients suffering from HS are novel biomarker candidates and potential therapeutic targets for HS.

2023-12-05 | GSE245451 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data