Transcriptomics

Dataset Information

0

Gene expression profiling of cancer cells purified from prostate cancer bone metastasis mouse model


ABSTRACT: The study aimed to determine mechanisms of macrophage promotion of anti-androgen resistance of prostate cancer bone disease. For this purpose, we developed a novel prostate cancer bone metastasis mouse model, MycCaP-Bo, via multiple rounds of in vivo selection of bone homing cells following intra-cardiac inoculation of a murine prostate cancer cell line, MycCaP cells. Cancer cells were purified from bone metastasis using fluoresent accelerated-cell sorting (FACS) based on their iRFP expression. Cancer cells were purified from treatment- naïve tumours, resistant tumours and resistant tumours with short-term depletion of macrophages. RNA was extracted from purified cancer cells and profiled using next-generation sequencing.

ORGANISM(S): Mus musculus

PROVIDER: GSE156427 | GEO | 2023/01/29

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| PRJNA657871 | ENA
2021-07-01 | GSE174613 | GEO
2017-08-30 | PXD006252 | Pride
2023-09-26 | GSE210729 | GEO
2013-01-17 | GSE39396 | GEO
2022-02-25 | GSE190928 | GEO
2015-09-30 | GSE73044 | GEO
2013-01-17 | GSE39395 | GEO
2024-02-22 | GSE253815 | GEO
2008-05-01 | GSE8001 | GEO