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Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis

ABSTRACT: Proper lung function relies on precisely balanced numbers of specialized epithelial cell types that work together and are maintained in homeostasis. We describe essential roles for the transcriptional regulators Yap and Taz, which are key effectors of Hippo pathway signaling, in maintaining lung epithelial homeostasis. We report that conditional deletion of Yap1/Yap and Wwtr1/Taz in the lung epithelium of adult mice results in severe defects with consequent animal lethality. Phenotypes associated with Yap/Taz deletion include alveolar defects and a striking development of goblet cell metaplasia throughout the airways. We performed gene expression analysis of wild type and Yap/Taz null primary mouse airway epithelial cells in order to define Yap/Taz controlled gene expression.

ORGANISM(S): Mus musculus

PROVIDER: GSE156525 | GEO | 2021/08/09

REPOSITORIES: GEO

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Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis (ChIP-seq)

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Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis

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