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CTCF HiChIP data in A673 Ewing sarcoma cell lines (siCT & siSA2)

ABSTRACT: STAG2, a member of cohesin, is one of the most recurrently mutated genes in human cancer. Here, we investigated STAG2 function in the context of Ewing sarcoma, an aggressive bone tumor driven by EWS-FLI1 oncogene chimeric transcription factor. A673 Ewing sarcoma cell line was trasfected with siCT or 2 different siRNA targetting STAG2 during 72h and CTCF HiChIP experiments were preformed for each conditions. Analyses of HiChIP data show that STAG2 knowck-down alters CTCF-anchored loop extrusion.

ORGANISM(S): Homo sapiens

PROVIDER: GSE156650 | GEO | 2021/04/29

REPOSITORIES: GEO

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HiChIP data in A673 & TC71 Ewing cell lines (STAG1 and STAG2 knock-out)

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CTCF HiChIP data in A673 Ewing sarcoma cell lines (siCT & siSA2)

Project description:CTCF HiChIP data in A673 Ewing sarcoma cell lines (siCT & siSA2)

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ChIP-seq data in A673 & TC71 Ewing cell lines (STAG1 and STAG2 knock-out)

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