The NSL complex is required for telomere maintenance and primary piRNA biogenesis from telomeric clusters
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ABSTRACT: Telomeres cap and protect chromosome ends. Drosophila telomeres consist of repetitive sequences dominated by retrotransposons. Telomeric sequences are transcribed and participate in a negative feedback loop in which they are processed into self-targeting piRNA on the one hand and are serve as the sole source of the transposase responsible for telomere maintenance on the other hand. We show that the tight regulation of the expression of telomeric sequences in the germline is regulated by the NSL complex. As a consequence, both primary biogenesis from telomeric piRNA clusters as well as telomere stability are impaired in cells following NSL complex depletion.
ORGANISM(S): Drosophila melanogaster
PROVIDER: GSE156897 | GEO | 2021/08/26
REPOSITORIES: GEO
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