Genomics

Dataset Information

0

Human senescence ATAC-seq [I]


ABSTRACT: Mammalian aging is characterized by the progressive loss of tissue integrity and function manifesting in ill health and increased risk for developing multiple chronic conditions. Accumulation of senescent cells in aging tissues partly contributes to this decline as targeted depletion of senescent cells in vivo ameliorates many age-related phenotypes. However, the fundamental molecular mechanisms responsible for the decline of cellular health and fitness during senescence and aging are largely unknown. In this study, we investigated whether chromatin-mediated loss of transcriptional fidelity, known to contribute to fitness and survival in yeast and worms, also occurs during human cellular senescence and mouse aging. Our findings reveal that aberrant transcription initiation inside genes is widespread in senescence and aging. It co-occurs with changes in the chromatin landscape and formation of non-canonical transcription start sites. Interventions that alter spurious transcripts have dramatic consequences on cellular health primarily affecting intracellular signal transduction pathways. We propose that spurious transcription is a conserved hallmark of aging that promotes a noisy transcriptome and a degradation of coherent transcriptional networks.

ORGANISM(S): Homo sapiens

PROVIDER: GSE156910 | GEO | 2023/01/02

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2023-01-02 | GSE158392 | GEO
2023-01-02 | GSE156828 | GEO
2023-01-02 | GSE156658 | GEO
2023-01-02 | GSE158391 | GEO
2023-01-02 | GSE157489 | GEO
2013-11-14 | E-GEOD-49108 | biostudies-arrayexpress
2024-05-24 | GSE263929 | GEO
2024-05-24 | GSE263928 | GEO
2024-05-24 | GSE263927 | GEO
2024-05-24 | GSE263926 | GEO