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YTHDF2 regulates maternal transcriptome degradation and embryo development in goat

ABSTRACT: Little information is known regarding the maternal mRNA clearance and mechanisms behind it in farm animals. In the present study, we determined 3362 differentially expressed genes as the maternal mRNAs in goat using RNA-seq. We further reported that knockdown of YTHDF2 led to decreased blastocyst rate and impaired the maternal mRNAs clearance by downregulation of decapping enzymes DCP1A and DCP2, and the de-adenlyase CNOT1 and CNOT11.

ORGANISM(S): Capra hircus

PROVIDER: GSE156924 | GEO | 2020/08/27

REPOSITORIES: GEO

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