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Diverse CGG binding proteins across eukaryotes produced by independent domestications of hAT transposons

ABSTRACT: The human transcription factor (TF) CGGBP1 (“CGG Binding Protein”) is conserved only in amniotes, and is believed to derive from the zf-BED and Hermes transposase DNA-binding domains (DBDs) of a hAT DNA transposon. Here, we examine the DNA binding preferences of a wide variety of metazoan CGGBP1-like TFs with this bipartite domain using PBM experiments. The derived motifs are available at ...

ORGANISM(S): Erpetoichthys calabaricus Fundulus heteroclitus Mola mola Locusta migratoria Amphiprion ocellaris Petromyzon marinus Austrofundulus limnaeus Acyrthosiphon pisum Rhipicephalus appendiculatus Labeo rohita Rhodnius prolixus Anabarilius grahami Aedes aegypti Chrysemys picta Salarias fasciatus Crocodylus porosus Homo sapiens Latimeria chalumnae Hippocampus comes Sphaeramia orbicularis Sparus aurata Rhizophagus irregularis Salmo salar Culex quinquefasciatus Kryptolebias marmoratus Nematostella vectensis synthetic construct Anabas testudineus Hofstenia miamia Gallus gallus Paramormyrops kingsleyae Acanthochromis polyacanthus Amphiprion percula Acipenser ruthenus Hucho hucho Cyprinus carpio

PROVIDER: GSE157085 | GEO | 2021/02/09

REPOSITORIES: GEO

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The amniote-conserved DNA-binding domain of CGGBP1 restricts cytosine methylation of transcription factor binding sites in proximal promoters to regulate gene expression (HTS)

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