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ScRNA seq analysis of adult CD34+ cells ex vivo cultured with Delta1ext-IgG under normoxia or hypoxia

ABSTRACT: We demonstrate that ex vivo culture of human adult hematopoietic stem and progenitor cells with Delta1ext-IgG under hypoxia limits endoplasmic reticulum stress in long-term repopulating hematopoietic stem cells and, to a lesser extent, in lineage committed progenitors compared to normoxic cultures. Data were submitted on behalf of Dr. Larochelle's lab at the NIH.

ORGANISM(S): Homo sapiens

PROVIDER: GSE157321 | GEO | 2021/07/24

REPOSITORIES: GEO

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bulkRNA seq analysis of adult CD34+ cells ex vivo cultured with Delta1ext-IgG under normoxia or hypoxia

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