IFN alpha-induced gene expression in human NK cells
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ABSTRACT: NK cells are believed to contribute to the control of hepatitis C virus infection and pathogenesis of liver disease. Standard treatment of both acute and chronic hepatitis C is based on the administration of interferon alpha, however, the effects of type I interferons on human NK cells have not been studied in the context of hepatitis C. We therefore first performed a microarray screen for genes differentially regulated in human NK cells after stimulation of PBMC with recombinant interferon alpha-2b. One of the genes upregulated was TRAIL which was confirmed in vitro on the protein level. Keywords: Interferon alpha; human NK cells; stimulation for 6 hours; cells sorted after stimulation of whole PBMC
ORGANISM(S): Homo sapiens
PROVIDER: GSE15743 | GEO | 2010/08/18
SECONDARY ACCESSION(S): PRJNA116885
REPOSITORIES: GEO
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