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MicroRNA profiling of human neural stem cells

ABSTRACT: To investigate global changes of miRNA profiles upon differentiation of human neural stem cells, we applied massively parallel sequencing (MPS) technology to an immortalized neural stem cell (HB1.F3) and its differentiated cell (F3.Olig2) lines. We identified 339 known miRNAs, out of which 170 miRNAs are up-regulated in F3.Olig2, while only 59 miRNAs in HB1.F3. We also identified 150 novel miRNA candidates.

ORGANISM(S): Homo sapiens

PROVIDER: GSE15756 | GEO | 2013/05/23

SECONDARY ACCESSION(S): PRJNA116783

REPOSITORIES: GEO

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MicroRNA profiling of human neural stem cells

Project description:To investigate global changes of miRNA profiles upon differentiation of human neural stem cells, we applied massively parallel sequencing (MPS) technology to an immortalized neural stem cell (HB1.F3) and its differentiated cell (F3.Olig2) lines. We identified 339 known miRNAs, out of which 170 miRNAs are up-regulated in F3.Olig2, while only 59 miRNAs in HB1.F3. We also identified 150 novel miRNA candidates. Sequencing miRNAs from an immortalized neural stem cell (HB1.F3) and its differentiated cell (F3.Olig2) lines

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