Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions
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ABSTRACT: The purpose of this project was to investigate whole genome expression in primary microglia cultured from homozygous Trem2 R47H knock-in mice versus wild type littermates under basal conditions and in response to IL-4 treatment. The primary phenotype of microglia from Trem2 R47H knock-in mice was decreased expression levels of Trem2. IL-4 induced the expression of an anti-inflammatory programme of genes in microglia, which was attenuated when Trem2 expression was decreased.
ORGANISM(S): Mus musculus
PROVIDER: GSE157891 | GEO | 2020/09/30
REPOSITORIES: GEO
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