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RNA Sequencing of HCC cells after lenvatinib, gefitinib, and combination treatment

ABSTRACT: Using a kinome-centred CRISPR/Cas9 genetic screen, we identify here that inhibition of the epidermal growth factor receptor (EGFR) is synthetic lethal with lenvatinib in liver cancer cells. We found that the combination of the EGFR inhibitor gefitinib and lenvatinib displays potent anti-proliferative effect in HCC cell lines that express EGFR in vitro and of xenografted HCC cell lines or patient-derived HCC tumours in mice. Herre, we analyzed the different transcriptome profiling of HCC cells treated with DMSO, lenvatinib, gefitinib, and lenvatinib plus gefitinib by RNA-sequencing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE157905 | GEO | 2021/07/22

REPOSITORIES: GEO

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