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Next generation sequencing transcriptome analysis of colonic epithelial cells from bone marrow transplant recipient mice

ABSTRACT: Alloimmune T cell mediated gastrointestinal graft-versus-host disease (GI-GVHD) occur after bone marrow translantation (BMT). GI-GVHD cause significant morbidity and mortality. Immunosuppression therapies have shown good results with adverse effects, but are still incomplete. The biology of GVHD are often understood from the immune cell perspectve, but the pathogenesis and severity from host IEC traget cell perspective remain undefined. We used next generation sequencing transcriptome to detail the gene expression of colonic epithelial cells underlying the profile changes between the syngeneic recipient and allogeneic recipient.

ORGANISM(S): Mus musculus

PROVIDER: GSE158259 | GEO | 2021/04/01

REPOSITORIES: GEO

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