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Characterization of young and aged lung tissue RNA 60 days post-influenza infection

ABSTRACT: To identify molecular characteristics of young and aged lungs post-influenza infection, we isolated RNA from lungs 60 days post-infection and examined by bulk RNAseq. We found a large number of genes remain upregulated in aged compared to young lungs. Comparison with expression of immune system-related genes from Nanostring expriments indicated this was largely infection-induced rather than baseline differences between age. This indicates that aged lungs fail to return to homeostasis following a viral respiratory infection

ORGANISM(S): Mus musculus

PROVIDER: GSE159066 | GEO | 2020/10/06

REPOSITORIES: GEO

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