Transcriptomics

Dataset Information

0

Immunologically hot phenotype is associated with response to PD-1/PD-L1 inhibitors in patients with advanced head and neck squamous cell carcinoma.


ABSTRACT: Ongoing immunomodulatory strategies in tumors characterized by an overall hot immune phenotype may improve prognosis of head and neck squamous cell carcinomas (HNSCC). Our objective was to develop a reliable and stable scoring system for the identification of immunologically hot HNSCC and to evaluate its association with response to immunotherapies. A Hot Oral Tumor (HOT) score was developed using data from The Cancer Genome Atlas. HOT score was computed in 102 patients with HNSCC treated with immunotherapy targeting PD-1/PD-L1 in the context of clinical trials. High HOT score was associated with a statistically significant improved clinical outcome.

ORGANISM(S): Homo sapiens

PROVIDER: GSE159067 | GEO | 2022/07/07

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-07-07 | GSE161537 | GEO
2022-07-07 | GSE162520 | GEO
2022-07-07 | GSE159141 | GEO
2024-08-01 | GSE249466 | GEO
2021-09-27 | GSE180347 | GEO
| PRJNA667509 | ENA
| PRJNA678660 | ENA
2016-10-11 | GSE84789 | GEO
2016-10-11 | GSE84797 | GEO
| PRJNA682139 | ENA